| Pair Name | Gambogic acid, NaI*131 | ||
| Phytochemical Name | Gambogic acid (PubChem CID: 9852185 ) | ||
| Anticancer drug Name | NaI*131 (PubChem CID: / ) | ||
| Structure of Phytochemical |
|
Download
2D
MOL
3D
MOL
|
|
| Structure of Anticancer Drug |
|
Download
2D
MOL
3D
MOL
|
|
| Pair Name | Gambogic acid, NaI*131 | |||
| Disease Info | [ICD-11: 2C25.Z] | Lung cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | ABCB1 | hsa5243 | |
| Down-regulation | Expression | TP53 | hsa7157 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| In Vitro Model | A549/DDP | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_C0W4 |
| Result | The two drugs appear to have a synergistic effect on apoptosis of A549/DDP cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Role of gambogic acid and NaI131 in A549/DDP cells. Oncol Lett. 2017 Jan;13(1):37-44. doi: 10.3892/ol.2016.5435. | Click |
